Award
NIH Reporter #5R01HL164806-04
Regulation of CSE-Derived Hydrogen Sulfide in the Heart
Recipient
Emory University, Atlanta, GA, United States
Award Amount
$514,162.00
Ceiling
$514,162.00
Awarded
March 20, 2026
Identifier
5R01HL164806-04
Research project funded to study the regulation of hydrogen sulfide production in the heart and its role in energy metabolism and cardiovascular health.
Description
This project investigates the regulation of hydrogen sulfide (H2S) production in the heart, focusing on the enzyme CSE and its regulation via phosphorylation and sulfhydration. The study aims to understand how H2S maintains energy metabolism during nutrient stress by modulating lipid droplet mobilization and interaction with mitochondria, with potential implications for cardiovascular therapies.