Award
NIH Reporter #5P01AI127335-09
Role of HCMV UL7-8 genes in the regulation of host cell signaling during viral latency and reactivation
Recipient
Oregon Health & Science University, Portland, OR, United States
Award Amount
$341,333.00
Ceiling
$341,333.00
Awarded
August 08, 2025
Identifier
5P01AI127335-09
This NIH-funded project studies the role of HCMV UL7 and UL8 genes in regulating host cell signaling during viral latency and reactivation, aiming to understand mechanisms that influence viral reactivation and cell survival in transplant recipients.
Description
Human cytomegalovirus (HCMV) is a β-herpesvirus infecting 44-100% of the population and remains a significant cause of morbidity and mortality in solid organ transplant (SOT) and allogeneic hematopoietic stem cell transplant (SCT) recipients. The project investigates the role of HCMV UL7 and UL8 genes in viral reactivation and latency, focusing on their interaction and impact on cellular signaling pathways and apoptosis in infected cells.