Award
National Heart, Lung, and Blood Institute 5R44HL170817-02
5-Minute Point-of-Care Anti-Factor Xa Test for Emergent Patient Management
Recipient
National Heart Lung and Blood Institute (NHLBI)
Award Amount
$1,007,678.00
Ceiling
$1,007,678.00
Awarded
August 29, 2025
Identifier
5R44HL170817-02
NIH/NHLBI awarded approximately $1,007,678 for a project to develop a rapid 5-minute point-of-care test for anti-Factor Xa activity to improve emergency patient management, including validation and clinical testing for FDA clearance.
Description
The project aims to develop a rapid, cost-effective point-of-care test for anti-Xa activity and hemoglobin to guide emergency management of bleeding and strokes. The project involves developing a system that provides results within 5 minutes, significantly faster than current central lab tests. It includes validation and calibration of the device, performance testing with various drugs, and clinical validation for FDA clearance. The development leverages proprietary fluorogenic substrates and microfluidic technology and aims to enable use in ambulances, emergency rooms, and surgical settings.