Award
National Institute of Environmental Health Sciences 5R01ES035813-02
Does lead (Pb) poisoning impair brain development by affecting how thyroid hormone gets into the brain?
Recipient
Virginia Polytechnic Institute and State University, Blacksburg, VA
Award Amount
$320,000.00
Ceiling
$320,000.00
Awarded
March 04, 2025
Identifier
5R01ES035813-02
Research grant awarded to study the effects of lead poisoning on thyroid hormone transport in brain development using amphibian models, aiming to understand mechanisms and develop therapies.
Description
This project investigates how lead (Pb) impacts thyroid hormone distribution into the brain, focusing on the expression and function of thyroid hormone distributor proteins in the choroid plexus of Xenopus laevis tadpoles. The research aims to determine if Pb impairs thyroid hormone-dependent brain development mechanisms, potentially leading to therapies for Pb poisoning.