Award
NIH Reporter #5K08AI168495-04
Establishing the impact of roseolovirues on development of autoimmunity due to loss of central tolerance
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$194,132.00
Ceiling
$194,132.00
Awarded
July 01, 2026
Identifier
5K08AI168495-04
Research project funded by NIAID to study how roseoloviruses affect immune tolerance and contribute to autoimmune diseases by impacting thymic epithelial cells and T cell development.
Description
Murine roseolovirus (MRV) is a beta-herpesvirus genetically related to human roseoloviruses HHV-6 and HHV-7, associated with autoimmune disease. This project aims to define the mechanism by which roseoloviruses induce autoimmune disease through impact on central tolerance, focusing on medullary thymic epithelial cells (mTECs) and T cell receptor repertoire.