Award
National Cancer Institute 5U54CA302426-02
Project 2: Inter-relationship of Race, the Microbiome, Innate Immune System, and Immunotherapy Response in Endometrial Cancer
Recipient
University of North Carolina at Chapel Hill
Award Amount
$394,979.00
Ceiling
$394,979.00
Awarded
August 05, 2026
Identifier
5U54CA302426-02
A research grant awarded to study racial disparities in endometrial cancer by examining the microbiome and immune system's role in immunotherapy response, aiming to improve treatment outcomes through microbiota-directed interventions and personalized dosing of PD-1 inhibitors.
Description
This research grant project investigates the inter-relationship between race, the microbiome, the innate immune system, and immunotherapy response in endometrial cancer. It aims to understand racial disparities in endometrial cancer outcomes, focusing on differences in microbiota profiles and innate immune system activity between Black and White women, and how these factors affect response to PD-1 inhibitor immunotherapy. The study includes clinical studies, microbiome analysis, and mechanistic mouse model experiments to develop microbiota-directed interventions and optimize immunotherapy dosing.