Award
NIH Reporter #5U19AG063911-07
Biofluid Core
Recipient
Mayo Clinic Rochester, Rochester, MN, United States
Award Amount
$1,921,495.00
Ceiling
$1,921,495.00
Awarded
July 31, 2026
Identifier
5U19AG063911-07
The Biofluid Core project funded by the National Institute on Aging aims to develop and refine fluid biomarkers for FTLD diagnosis, disease progression monitoring, and treatment development, with a focus on early detection and intervention.
Description
The Biofluid Core (BFC) project aims to develop novel fluid biomarkers for establishing diagnosis, detecting early-stage disease, monitoring disease progression, and measuring downstream intervention effects in frontotemporal lobar degeneration (FTLD). The project also focuses on identifying biomarkers that predict conversion from asymptomatic mutation carrier status to overt disease, supporting prevention and early treatment trials. The BFC builds upon previous progress and uses strategies such as unbiased proteomics, extracellular vesicles, and novel proteins produced by TDP-43 dysfunction. It collaborates with academia and industry and is supported by the National Centralized Repository for Alzheimer’s Disease and Related Dementias.