Award
National Cancer Institute 5R01CA295997-02
Mechanisms and Consequences of PAX2 Inactivation in the Initiation of Endometrial Carcinogenesis
Recipient
UT Southwestern Medical Center
Award Amount
$551,975.00
Ceiling
$551,975.00
Awarded
December 05, 2025
Identifier
5R01CA295997-02
NIH awarded a research grant to UT Southwestern Medical Center to study the molecular mechanisms and consequences of PAX2 inactivation in endometrial cancer, aiming to improve understanding for early detection, diagnosis, prevention, and treatment.
Description
This NIH R01 grant supports research on the molecular mechanisms of PAX2 loss in endometrial cancer, focusing on epigenetic repression and tumor suppressor functions. The project involves multiple investigators and aims to elucidate early precancerous changes and functional consequences of PAX2 inactivation.