National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK134064-04

Defining GATA4's Molecular Function in Gastric Cell Biology

Research project funded by the National Institute of Diabetes and Digestive and Kidney Diseases to study the molecular function of GATA4 in gastric parietal cells, aiming to understand mechanisms underlying gastric diseases.

Description

This project aims to investigate the role of the transcription factor GATA4 in parietal cell function, using mouse models and human gastric organoids, to elucidate pathways essential for maintaining parietal cell health and preventing gastric disease. Gastric parietal cells play a critical role in gastrointestinal function by secreting acid for digestion and protection against infection and by synthesizing growth factors that influence the development of other cell types including zymogenic chief cells. Dysfunction of these cells underlies diseases such as chronic gastritis, peptic ulcer disease, Helicobacter pylori related peptic ulcer disease, and cancer.

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