Award
NIH Reporter #5P30DA056410-04
Bioactive Lipid Mediators Core (BLMC)
Recipient
TRUSTEES OF INDIANA UNIVERSITY, BLOOMINGTON, IN, UNITED STATES
Award Amount
$323,513.00
Ceiling
$323,513.00
Awarded
July 30, 2026
Identifier
5P30DA056410-04
This NIH grant funds the Bioactive Lipid Mediators Core to study lipid signaling changes due to chronic drug use, develop analytical techniques, analyze sex differences, and train undergraduates in lipidomics.
Description
The Bioactive Lipid Mediators Core (BLMC) supports research on the systemic and neurophysiological effects of chronic drug use on lipid signaling. It focuses on lipid biomarkers in tissues such as plasma, CNS, liver, and breast milk, aiming to understand their role in drug use disorders. The project involves developing analytical techniques for small molecule lipid metabolites, evaluating lipidomics patterns in animal models of drug use (THC, opioids, alcohol), analyzing sex differences in lipid signaling in the CNS, studying lipid changes in breast milk due to drug exposure, and creating data science tools for lipidomics data interpretation. The program also emphasizes training undergraduate students in lipidomics and mass spectrometry.