NIH Reporter #5I21RX004644-04

Feasibility of Using PET Imaging for Detection of Treatment-Induced Changes in Chronic Neuroinflammation Following TBI

This award supports a study to develop a preclinical platform using PET imaging to detect chronic neuroinflammation following traumatic brain injury (TBI) and to evaluate methylphenidate treatment effects, aiming for clinical translation.

Description

The purpose of this study is to test the feasibility of developing a preclinical platform for the study of TBI-induced chronic neuroinflammation. The study will utilize PET imaging to detect and surveil inflammation, and will evaluate the efficacy of pharmacologic treatment (methylphenidate) to upregulate central noradrenergic and dopaminergic innervation. The research addresses a significant clinical problem related to secondary brain injury and TBI disabilities, with potential for rapid clinical translation.

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