Award
National Institute on Drug Abuse 5R01DA058666-03
Short Sleep Duration as a Predictor of Methamphetamine Intake: Role of Orexin Mechanisms
Recipient
University of Mississippi Medical Center
Award Amount
$780,511.00
Ceiling
$780,511.00
Awarded
April 29, 2026
Identifier
5R01DA058666-03
Research project funded by NIDA to study how orexin system dysregulation related to short sleep duration affects methamphetamine intake in female monkeys, aiming to understand addiction vulnerability.
Description
This project investigates the role of orexin mechanisms in sleep and methamphetamine use, hypothesizing that dysregulation of orexin processes contributes to short sleep phenotypes and increases vulnerability to methamphetamine addiction. The research involves evaluating orexin system dysregulation, its effect on sleep, and its role in methamphetamine reinforcement in female monkeys.