Award
NIH Reporter #5K08AI183990-03
ENHANCEMENT OF CD4CAR T-CELL PERSISTENCE IN VIVO
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$186,408.00
Ceiling
$186,408.00
Awarded
July 20, 2026
Identifier
5K08AI183990-03
The award supports research to improve the persistence and function of HIV-targeting CD4CAR T cells to achieve durable viral remission without ART, using novel strategies including IL15 cytokine enhancement and validation in primate models.
Description
This project aims to advance HIV-targeting CAR T cells with enhanced long-term persistence to achieve viral suppression without the need for antiretroviral therapy (ART). The research focuses on overcoming the effect of soluble antigen on CD4CAR T-cell function and extending their persistence using IL15 cytokine strategies, validated in a non-human primate model of chronic HIV infection.