Award
National Institute on Aging 5R01AG066921-05
Androgen Replacement to Improve Patient-Important Outcomes in Men with Opioid-Induced Hypogonadism
Recipient
BRIGHAM AND WOMEN'S HOSPITAL
Award Amount
$808,444.00
Ceiling
$808,444.00
Awarded
July 28, 2026
Identifier
5R01AG066921-05
This award funds a clinical trial to evaluate testosterone replacement therapy in men with opioid-induced hypogonadism and chronic back pain, aiming to improve pain outcomes and understand underlying mechanisms.
Description
A large randomized, double-blind, placebo-controlled trial in men with chronic back pain and opioid-induced hypogonadism to assess the efficacy of testosterone replacement on pain perception and to determine the mechanism behind anti-nociceptive properties of testosterone. The study includes quantitative sensory testing and fMRI to understand pain processing mechanisms. Outcomes include clinical pain, quality of life, mood, and depression.