Award
NIH Reporter #5R01HL166518-04
Spatiotemporal regulation of polyploidy in zebrafish cardiac tissue regeneration
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV
Award Amount
$692,838.00
Ceiling
$692,838.00
Awarded
August 10, 2026
Identifier
5R01HL166518-04
Research project funded by the National Heart Lung and Blood Institute to study the regulation and role of polyploidy in zebrafish heart regeneration, focusing on signaling pathways and tissue repair mechanisms.
Description
The project aims to understand the signaling pathways, including mechanical cues and Yap signaling, that regulate spatiotemporal polyploidization during epicardial regeneration in adult zebrafish heart tissue. It explores the functional significance of epicardial polyploidy in heart regeneration and its implications in pathological conditions such as lung injury, acute kidney injury, and cancer.