Award
National Institute of Mental Health 1R01MH138375-01A1
The effect of right dlPFC cTBS on acute measures of anxiety, functional connectivity, and TMS-evoked BOLD responses
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$762,440.00
Ceiling
$762,440.00
Awarded
March 25, 2026
Identifier
1R01MH138375-01A1
This award funds research to study the effects of continuous theta burst stimulation to the right dorsolateral prefrontal cortex on anxiety-related brain activity and behavior using TMS and fMRI.
Description
The project aims to develop an interleaved TMS/fMRI protocol to assess the effects of neuromodulatory theta burst stimulation on neural and behavioral measures related to anxiety expression. The study will determine the impact of continuous theta burst stimulation (cTBS) to the right dorsolateral prefrontal cortex (dlPFC) on TMS-evoked fMRI responses in anxious subjects, hypothesizing that cTBS will reduce activity in downstream targets and thus decrease anxiety.