Award
National Institute of Allergy and Infectious Diseases 1F32AI197474-01
Regulation of amidase activity during spore development
Recipient
Tufts University Boston, MA, United States
Award Amount
$75,880.00
Ceiling
$75,880.00
Awarded
March 30, 2026
Identifier
1F32AI197474-01
The project focuses on understanding the regulation of CwlD amidase activity during spore development in C. difficile to inform anti-spore germination therapies using genetic, biochemical, and structural methods.
Description
This project aims to elucidate the molecular mechanisms regulating CwlD amidase activity, localization, and function during spore development in Clostridioides difficile, with the goal of developing therapies to prevent disease transmission by inhibiting spore germination.