Award
NIH Reporter #1ZIABC011830-08
Control of cell cycle commitment by APC-C-Cdh1
Recipient
DIVISION OF BASIC SCIENCES - NCI
Award Amount
$647,314.00
Ceiling
$647,314.00
Awarded
October 04, 2023
Identifier
1ZIABC011830-08
The award supports research on cell cycle regulation and its disruption by DNA damage and cancer drugs, aiming to prevent cancer-related genome instability.
Description
This project investigates the mechanisms by which cells exit the cell cycle prematurely, particularly focusing on the effects of DNA damage and CDK4/6 inhibitors, with the goal of developing treatments to prevent aneuploidy and genome instability associated with aggressive cancers.