Award
National Institute of General Medical Sciences 5R01GM157608-02
DMS/NIGMS 2: The mathematics of epigenetic regulation in human cells
Recipient
University of Texas Dallas, Richardson, TX
Award Amount
$255,291.00
Ceiling
$255,291.00
Awarded
August 08, 2025
Identifier
5R01GM157608-02
The project develops accurate models of epigenetic mechanisms by integrating epigenetic regulators into human cells and modeling gene expression kinetics to understand stability and dynamic behavior, with implications for developmental biology and medicine.
Description
This project aims to assemble and stably integrate epigenetic regulators and complex circuits in human cells, serving as biomolecular ground truth for inference and characterization. It will develop methodologies for rapid assembly of CRISPR-based epigenetic regulators, study properties of epigenetic circuits in human cell lines, and create a theoretical framework to model stochastic gene expression kinetics. The models will be validated with experimental data to predict multistability, phase transitions, and oscillations.