National Heart, Lung, and Blood Institute 5R01HL145478-08

Donor nonclassical monocytes mediate primary graft dysfunction and remote organ injury following lung transplant surgery

This NIH-funded research project investigates how donor nonclassical monocytes contribute to primary graft dysfunction and remote organ injury after lung transplant surgery. The study aims to understand the mechanisms of monocyte interaction and activation to develop new therapeutic strategies to improve transplant outcomes.

Description

The project aims to investigate the role of nonclassical monocytes in primary graft dysfunction (PGD) and injury in other organs following lung transplant. The project has two aims: to study how host classical monocytes promote the migration and retention of donor nonclassical monocytes in other organs, and to understand the opposing roles of donor and recipient nonclassical monocytes in PGD and remote organ injury. The insights gained will help develop new strategies to improve outcomes after lung transplant surgery.

View original record