Award
NIH Reporter #5R35CA294015-02
Navigating Pathways of Innate Immunity and Epigenetic Memory in Checkpoint Immunotherapy
Recipient
BETH ISRAEL DEACONESS MEDICAL CENTER
Award Amount
$828,758.00
Ceiling
$828,758.00
Awarded
July 27, 2026
Identifier
5R35CA294015-02
This award supports research on the role of immune checkpoints in innate immunity and epigenetic memory to improve cancer immunotherapy, focusing on myeloid cells and personalized treatment strategies.
Description
The project aims to investigate the impact of immune checkpoints on innate immunity and epigenetic memory in cancer immunotherapy. Focus areas include emergency myelopoiesis, myeloid-specific immune checkpoint targeting, and epigenetic changes in hematopoietic stem and progenitor cells (HSPC). The project will utilize CRISPR screens and humanized NSG mice for personalized therapy development.