Award
NIH Reporter #1R56HL169445-01A1
Alternative polyadenylation in Right Ventricular Fibrosis
Recipient
Methodist Hospital Research Institute, Houston, TX, United States
Award Amount
$760,708.00
Ceiling
$760,708.00
Awarded
September 25, 2024
Identifier
1R56HL169445-01A1
Research project studying alternative polyadenylation's role in right ventricular fibrosis to find therapeutic targets for RV failure due to pulmonary hypertension.
Description
This project investigates the role of alternative polyadenylation (APA) in right ventricular (RV) fibrosis, a key factor in RV failure caused by pulmonary hypertension. The research focuses on the regulation of APA by CPSF6 and the impact of oxidative stress marker 4-hydroxy-2-nonenal (4HNE) on CPSF6 expression. The study aims to identify therapeutic targets to mitigate RV fibrosis.