Award
National Institute of Neurological Disorders and Stroke 5R21NS136915-02
Metabolic treatment of neurological mitochondrial disorders
Recipient
University of Washington, Seattle, WA, United States
Award Amount
$194,375.00
Ceiling
$194,375.00
Awarded
April 10, 2025
Identifier
5R21NS136915-02
A research grant awarded to study metabolic treatments for neurological mitochondrial disorders by investigating nutrient metabolism shifts due to mTOR inhibition.
Description
This project explores the hypothesis that inhibition of the mammalian Target of Rapamycin (mTOR) promotes a shift in nutrient metabolism away from carbohydrates and toward fats in mitochondrial disorders caused by dysfunction of Complex I of the Electron Transport Chain. The project aims to determine the role of nutrient metabolism in the onset and treatment of neurological mitochondrial disorders.