Award
NIH Reporter #5P42ES030991-05
Epidemiological Study of Volatile Organic Compounds and Preterm Birth in Detroit
Recipient
Wayne State University, Detroit, MI, United States
Award Amount
$293,931.00
Ceiling
$293,931.00
Awarded
July 03, 2026
Identifier
5P42ES030991-05
A research project funded by the National Institute of Environmental Health Sciences to study the impact of volatile organic compounds on preterm birth in Detroit by recruiting pregnant women and analyzing biological markers.
Description
This study aims to establish a prospective birth cohort in metropolitan Detroit, recruiting approximately 1,100 pregnant women through Henry Ford Health System, to investigate the relationship between VOC exposure and preterm birth (PTB). The study will measure VOC metabolites in maternal urine, benzene protein adducts in the placenta, and inflammatory biomarkers in maternal blood, as well as analyze DNA methylation and gene expression in placental tissue. The objectives include assessing associations between VOC exposure and PTB, exploring mediation by inflammation and gene expression, and identifying sources of VOC exposure. The research will inform biomedical prevention and environmental remediation strategies.