Award
National Institute on Aging 1K23AG093103-01A1
Contributions of sex differences in the dynamic change of cognitive reserve across the cognitive spectrum of Alzheimer's disease and estrogen to cognitive reserve in typical aging
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$189,963.00
Ceiling
$189,963.00
Awarded
June 29, 2026
Identifier
1K23AG093103-01A1
The award funds research to understand sex differences in cognitive reserve in Alzheimer's disease, focusing on estrogen's role. It includes longitudinal and cross-sectional studies to clarify biological pathways affecting cognitive reserve and aims to prepare the principal investigator for independent research.
Description
This project aims to clarify sex differences in cognitive reserve related to Alzheimer's disease and investigate the role of estrogen. It involves longitudinal and cross-sectional studies focusing on aging, neuroimaging, biomarkers, and genetics. The research will assess the roles of biological sex and sex hormones on the risk of developing Alzheimer's disease through the lens of cognitive reserve, investigating dynamic changes across the cognitive spectrum and the contribution of estrogen in asymptomatic older adults.