Award
National Institute on Drug Abuse 5R01DA060228-02
Discovery of GPR52 ligand probes for cocaine use disorder
Recipient
University of Texas Med Br Galveston, Galveston, TX, United States
Award Amount
$795,090.00
Ceiling
$795,090.00
Awarded
May 26, 2026
Identifier
5R01DA060228-02
The award funds research to develop and evaluate GPR52 agonist probes as potential treatments for cocaine use disorder, aiming to advance therapeutic strategies for substance use disorders.
Description
This project focuses on developing small molecule probes targeting GPR52 to treat cocaine use disorder, with potential applications to other substance use disorders. The research aims to create and evaluate GPR52 agonist probes with favorable pharmacokinetics and pharmacodynamics for proof-of-concept in vivo models, advancing understanding of GPR52 as a therapeutic target and supporting development of medications for cocaine use disorder and related disorders.