Award
National Institute of Diabetes and Digestive and Kidney Diseases 5K08DK132496-05
Neoglycosylation Epitopes in Metaplasia and Cancer
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$165,062.00
Ceiling
$165,062.00
Awarded
January 26, 2026
Identifier
5K08DK132496-05
A five-year NIH-funded research career development program led by Jeffrey W. Brown at Washington University School of Medicine to study glycosylation epitopes in metaplasia and cancer, focusing on their role in cellular transformations and molecular mechanisms, aiming to establish an independent research program.
Description
This NIH-funded project aims to investigate the role of specific glycosylation epitopes in cellular transformations related to cancer, with a focus on sulfomucins and their associated molecular mechanisms. The work includes in vitro, organoid, and murine model studies to understand how these epitopes orchestrate metaplastic and oncogenic transformations in foregut metaplasias and cancer.