Award
National Institute of General Medical Sciences 5R35GM152012-03
Structure and function of chloride channels, transporters and scramblases
Recipient
Weill Medical College of Cornell University, New York, NY, United States
Award Amount
$567,825.00
Ceiling
$567,825.00
Awarded
March 04, 2026
Identifier
5R35GM152012-03
This NIH-funded project studies the structure and function of chloride channels and scramblases to understand their regulation and the impact of disease mutations, aiming to develop targeted treatments for related inherited disorders.
Description
Anion channels, active transporters, and lipid scramblases are integral membrane proteins that play key roles in human physiology, controlling processes such as epithelial salt reabsorption, neuromuscular excitability, blood coagulation, membrane fusion, and repair. The project aims to understand the molecular mechanisms of gating and regulation of two families of membrane transport proteins, the voltage-gated CLCs and the Ca2+-activated TMEM16s, focusing on CLC-1 and TMEM16E, and how mutations affect their structure-function relationships. The research will utilize state-of-the-art structural and functional techniques to study protein regulation and mutation effects, with the goal of developing targeted therapeutics based on structural insights.