Award
NIH Reporter #4R00AG078493-03
Investigating the role of cGAS signaling and microglial senscence in tauopathy
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$244,020.00
Ceiling
$244,020.00
Awarded
August 06, 2025
Identifier
4R00AG078493-03
Research project funded by the National Institute on Aging to study the role of cGAS signaling in tauopathy and Alzheimer's disease, aiming to understand molecular mechanisms and identify therapeutic targets.
Description
This project aims to elucidate the molecular mechanisms of cGAS activation in tauopathy and explore potential therapeutic targets for Alzheimer’s disease. It investigates the role of cGAS and nucleic acid sensing pathways in tau-mediated neurodegeneration, focusing on microglial responses and neuronal damage, using mouse and human models.