Award
National Institute on Aging 4RF1AG078338-02
Function of ceramide in extracellular vesicle-mediated neurodegenerative disease
Recipient
University of Kentucky
Award Amount
$1,033,249.00
Ceiling
$1,033,249.00
Awarded
September 02, 2025
Identifier
4RF1AG078338-02
NIH grant awarded to University of Kentucky to study ceramide's role in extracellular vesicles contributing to Alzheimer's disease neurotoxicity, aiming to develop sex-independent therapies.
Description
This NIH grant project aims to understand the role of ceramide in extracellular vesicle-mediated neurodegenerative disease, specifically Alzheimer's disease (AD). The research focuses on how ceramide-enriched extracellular vesicles called astrosomes contribute to neurotoxicity and AD pathology, with a goal to develop novel drug approaches effective in both sexes to prevent AD pathology and improve cognition.