Award
National Heart, Lung, and Blood Institute 5R01HL166317-04
Unraveling a parabrachial circuit for the state-dependent control of rapid breathing
Recipient
Seattle Children's Hospital
Award Amount
$868,128.00
Ceiling
$868,128.00
Awarded
March 05, 2026
Identifier
5R01HL166317-04
NIH grant awarded to Seattle Children's Hospital to study a neural circuit controlling rapid breathing in awake states, with implications for treating breathing-related disorders like panic disorder.
Description
This project aims to characterize a novel neural circuit in the parabrachial nucleus that controls rapid breathing specifically in the awake state. Using transgenic, viral vector, and optogenetic tools, the study will explore how this circuit influences respiratory patterns and its role in emotion-related breathing disorders such as panic disorder.