Award
NIH Reporter #5R01MH125557-05
CRCNS: Neural computations underlying sequence memory consolidation in sleep
Recipient
University of California, San Diego
Award Amount
$347,528.00
Ceiling
$347,528.00
Awarded
June 14, 2024
Identifier
5R01MH125557-05
NIH funded research project studying neural mechanisms of sequence memory consolidation during sleep using computational and experimental methods to improve understanding of cognitive performance and mental health.
Description
The project investigates how the brain stores and retrieves sequential information, fundamental to intelligent behavior. It explores hippocampal and neocortical mechanisms of sequence acquisition and consolidation during sleep, using computational models and in vivo experiments in mice. The goal is to understand how knowledge is extracted from experience, involving brain circuits and dynamics, to improve cognitive performance and memory, especially in mental health conditions like depression, schizophrenia, and PTSD.