Award
National Eye Institute 5R01EY034565-04
Optimizing methotrexate use for the management of chronic pediatric non-infectious uveitis
Recipient
Cincinnati Children's Hospital Medical Center
Award Amount
$560,861.00
Ceiling
$560,861.00
Awarded
April 06, 2026
Identifier
5R01EY034565-04
A longitudinal translational study aiming to optimize treatment for pediatric chronic non-infectious uveitis by identifying predictors of methotrexate responsiveness, utilizing advanced imaging, and exploring gene expression signatures to improve ocular health outcomes.
Description
This research will identify clinical, imaging, and biologic risk factors that predict a child’s responsiveness to methotrexate to help select the most optimal initial treatment for children with pediatric chronic non-infectious uveitis (NIU) that will control inflammation quickly, minimize ocular damage, and improve childhood vision.