# NIH Reporter #1R21AG104396-01

An Overlooked Steroid Hormone as a Driver of Cognitive Resilience

**Recipient:** National Institute on Aging

**Award Amount:** $451,000.00
**Ceiling:** $451,000.00

**Awarded:** August 17, 2026

**Identifier:** 1R21AG104396-01

This NIH award supports research on the steroid hormone ADIOL to understand its role in cognitive resilience and potential to reduce Alzheimer's disease risk.

### Description

The project investigates a steroid hormone, ADIOL, as a regulator of cognitive capacity, with mechanistic studies in mice and correlative studies in humans. The project aims to uncover steroid-based mechanisms to enhance cognitive healthspan and reduce vulnerability to Alzheimer’s disease and related dementias.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11442545)