Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK126772-05
Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine
Recipient
Cleveland Clinic Lerner COM-CWRU
Award Amount
$481,261.00
Ceiling
$481,261.00
Awarded
December 12, 2024
Identifier
5R01DK126772-05
The award supports research to understand how different strains of Bacteroides thetaiotaomicron induce anti-inflammatory responses in the intestine, with the goal of developing designer probiotics to treat IBD.
Description
This project aims to leverage strain-level variation in Bacteroides thetaiotaomicron to identify genes and molecules that confer anti-inflammatory capacity, advancing designer probiotic therapeutics for inflammatory bowel disease (IBD).