Award
National Institute of General Medical Sciences 5F32GM153139-02
The developmental origin of adult pluripotent stem cells
Recipient
Harvard University
Award Amount
$79,348.00
Ceiling
$79,348.00
Awarded
January 15, 2026
Identifier
5F32GM153139-02
NIH awarded a grant to Harvard University for research on the developmental origin and regulation of adult pluripotent stem cells, focusing on embryonic development and chromatin states in Hofstenia.
Description
This project aims to determine how the identity of adult pluripotent stem cell (aPSC) populations is established during development and retained in adult animals. The research focuses on embryonic development in Hofstenia to identify mechanisms for aPSC formation and the associated chromatin states. The project involves three specific aims: 1. Identify the molecular trajectory of aPSC formation. 2. Define the chromatin landscape associated with aPSCs during development. 3. Functionally assess transcription factors involved in stem cell specification and maintenance. The approach combines genomic and cellular biological strategies, leveraging the developmental lineage of aPSCs in Hofstenia. The research is significant for advancing understanding of stem cell regulation in development and may open new avenues in stem cell biology.