Award
National Institute of General Medical Sciences 5R35GM157207-02
Lysosomal membrane dynamics during stress
Recipient
Ohio State University, Columbus, OH
Award Amount
$393,750.00
Ceiling
$393,750.00
Awarded
February 10, 2026
Identifier
5R35GM157207-02
Research project funded by NIGMS to study lysosomal membrane dynamics and related disease mechanisms, including neurodegeneration and immune disorders, using advanced techniques and human macrophages derived from iPSCs.
Description
This project aims to understand lysosomal membrane dynamics under stress, focusing on a novel process called LYTL driven by LRRK2 kinase. The research will explore lysosomal quality control mechanisms, cellular responses to damage, and potential therapeutic targets.