National Institute of Environmental Health Sciences 1R01ES037601-01

Mast Cell Activation as a Common Mechanism of Pulmonary Toxicity by Chemical Threat Agents

This NIH-funded project investigates mast cell activation as a common mechanism of lung injury caused by various chemical threat agents, aiming to develop targeted therapies.

Description

The project aims to confirm the role of mast cells in lung injury caused by chemical threat agents such as nitrogen mustard, chloropicrin, and formaldehyde. Using mast cell deficient mouse models and a novel human lung-on-a-chip model with incorporated mast cells, the study seeks to establish activation of mast cells as a common mechanism across various chemical classes linked with pulmonary toxicity. The findings could lead to the development of targeted therapeutic interventions.

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