# NIH Reporter #1F31AI197725-01

Defining MARCO as an Innate Checkpoint

**Recipient:** University of Massachusetts Medical School Worcester

**Award Amount:** $38,153.00
**Ceiling:** $38,153.00

**Awarded:** May 15, 2026

**Identifier:** 1F31AI197725-01

The project investigates how MARCO regulates LPS detection and inflammatory cell death, including how interferons affect MARCO expression and whether MARCO deficiency increases susceptibility to sepsis.

### Description

Research fellowship project studying the role and regulation of MARCO, a proposed LPS decoy receptor, and its effects on immune surveillance, inflammasome activation, and sepsis.

[View original record](https://reporter.nih.gov/search/7RZVnLFgNEWpofIHyjL5uw/project-details/11318429)