Award
NIH Reporter #5R01HL174545-02
Roles for SGK1 in Cardiometabolic Heart Failure with Preserved Ejection Fraction
Recipient
Utah State Higher Education System--University of Utah, Salt Lake City, UT, United States
Award Amount
$641,545.00
Ceiling
$641,545.00
Awarded
August 10, 2026
Identifier
5R01HL174545-02
This award funds research to understand the molecular mechanisms of heart failure with preserved ejection fraction (HFpEF), focusing on the role of SGK1 in cardiometabolic HFpEF, aiming to develop new therapeutic strategies.
Description
Cardiovascular disease accounts for 1 in every 3 deaths in the US, typically as a result of pathological cardiac remodeling and subsequent heart failure, for which there is no cure. As the percentage of obese individuals continues to grow at an alarming rate, coming to the forefront in cardiovascular medicine is that the pathophysiology of the majority of heart failure patients involves a multi-organ syndrome in which cardiac, inflammatory, metabolic and other systems result in the diagnosis of what has been recently coined heart failure with preserved ejection fraction (HFpEF). The studies proposed here aim to decipher the molecular mechanisms contributing to HFpEF, with the anticipation that understanding these mechanisms will help us to develop novel and selective therapeutic avenues for intervention and, thus, reduce mortality from this form of cardiovascular disease and associated obesity-related diseases.