Award
NIH Reporter #5R00GM146028-05
Structural consequences of PKC-dependent phosphorylation of Kv7.2
Recipient
University of Arkansas at Fayetteville
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
August 14, 2026
Identifier
5R00GM146028-05
NIH funded research to study the structural effects of PKC-dependent phosphorylation on Kv7.2 channels to understand regulation mechanisms relevant to neuronal excitability diseases.
Description
This research project aims to elucidate how M channel activity is regulated by phosphorylation effects on Kv7.2 subunits, using advanced NMR techniques to determine structure and analyze binding affinities, with implications for therapies for neuronal excitability disorders.