Award
NIH Reporter #2R35GM142588-06
Biophysical mechanism and synthetic engineering of optically controlled Ca2+-powered supramolecular engines
Recipient
University of Colorado, Boulder, CO, United States
Award Amount
$2,165,625.00
Ceiling
$2,165,625.00
Awarded
August 13, 2026
Identifier
2R35GM142588-06
Research project focused on understanding calcium-responsive protein assemblies and developing AI-controlled synthetic cytoskeletons for intracellular force generation and artificial cell engineering.
Description
This project aims to dissect the structural, biochemical, and single-molecule mechanisms of contractility and integrate AI-driven control to develop programmable, adaptive force generation in synthetic cytoskeletons, enabling applications such as targeted cargo transport, shape modulation, and cell division-like deformations.