Award
National Institute on Aging 5R01AG072643-05
NPTX2: Preserving memory circuits in normative aging and Alzheimer's Disease
Recipient
University of Arizona
Award Amount
$1,098,582.00
Ceiling
$1,098,582.00
Awarded
April 14, 2025
Identifier
5R01AG072643-05
A multi-year NIH-funded research project investigating the role of the gene NPTX2 in memory preservation and cognitive decline related to aging and Alzheimer's disease using human and animal models.
Description
This project aims to understand the molecular and cellular bases of memory changes related to aging and Alzheimer's disease. It focuses on the gene NPTX2, which is involved in memory consolidation and brain resilience. The study will examine NPTX2 expression in human brain specimens, use human iPS neurons with familial mutations, and employ rat models to test the causal role of NPTX2 loss of function in circuit dysfunction and cognitive decline.