Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR081448-04
Individual cell bioprinting to generate multi-tissue type condensations for osteochondral tissue regeneration
Recipient
University of Illinois at Chicago
Award Amount
$422,057.00
Ceiling
$422,057.00
Awarded
February 10, 2026
Identifier
5R01AR081448-04
The award supports research on advanced 3D bioprinting techniques to engineer prevascularized osteochondral tissue constructs for improved treatment of osteochondral defects.
Description
This project proposes a scaffold-free cellular condensation strategy using 3D bioprinting of a cell-only bioink to create complex, high-resolution osteochondral tissues with prevascularized bone and cartilage phases. The project aims to optimize microgel properties for printing fidelity, engineer tissue constructs with controlled delivery of growth factors, and evaluate their clinical potential in a rabbit model.