Award
NIH Reporter #11309547
Functional consequences of high glucose culture on adoptive T cell therapies for cancer
Recipient
Not Specified
Award Amount
$55,114.00
Ceiling
$55,114.00
Awarded
April 09, 2026
Identifier
11309547
Research project studying the effects of high glucose culture conditions on T cell therapies for cancer, aiming to improve CAR-T cell therapy outcomes by optimizing culture media.
Description
The project focuses on understanding how high glucose levels in culture media affect T cell function and glycosylation, with implications for CAR-T cell therapy. The study aims to identify differentially O-GlcNAcylated proteins and assess the impact of inhibiting O-GlcNAcylation on T cell function. Findings will inform optimization of culture media formulations to improve patient responses in adoptive cell therapies.