Award
National Institute of Allergy and Infectious Diseases 5R01AI177594-03
Pathogenic B cell:CD4 T cell interactions in a novel B cell-dependent EAE mouse model of multiple sclerosis
Recipient
University of Iowa
Award Amount
$472,369.00
Ceiling
$472,369.00
Awarded
July 16, 2025
Identifier
5R01AI177594-03
NIH awarded a grant to the University of Iowa to study B cell and CD4 T cell interactions in a novel mouse model of multiple sclerosis, focusing on B cell roles beyond antibody production in MS pathology.
Description
This project uses a novel B cell-dependent, antibody-independent EAE model to study how B cells influence CD4 T cell responses and neuroinflammation in multiple sclerosis (MS). The research aims to elucidate B cell-mediated mechanisms, including antigen presentation and cytokine support, that shape pathogenic T cell responses and contribute to demyelination. The project is conducted at the University of Iowa within the Department of Pathology and is part of NIH's PA-20-185 funding opportunity.