Award
NIH Reporter #5R37CA285434-03
Development and validation of an autologous mouse model for the study of immune interactions with glioblastoma
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$727,211.00
Ceiling
$727,211.00
Awarded
June 03, 2026
Identifier
5R37CA285434-03
This award supports the development and validation of an autologous humanized mouse model to study immunotherapies in glioblastoma, using tumor tissue and matched immune cells from the same patient to ensure clinically relevant experimental outcomes.
Description
An autologous mouse model for glioblastoma immunotherapy research, developed by engrafting human immune system components, tumor tissue, and T cells from the same patient, allowing for relevant preclinical evaluation of immune responses and therapies.