Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 11320735
Integrase Inhibitors during pregnancy and Neurodevelopmental Outcomes: Underlying Mechanism and Therapeutic Intervention
Recipient
University of Nebraska Medical Center
Award Amount
$567,305.00
Ceiling
$567,305.00
Awarded
April 17, 2026
Identifier
11320735
Research project awarded to University of Nebraska Medical Center to study the effects of Dolutegravir during pregnancy on neurodevelopmental outcomes and develop safer drug delivery methods.
Description
The project focuses on evaluating the effects of Dolutegravir (DTG) during pregnancy, particularly its neurodevelopmental outcomes. The research involves studying the inhibition of MMPs by DTG and its impact on neurotoxicity. The project aims to develop long-acting nanoformulations for safer drug delivery during pregnancy. The funding is provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The project includes collaboration with clinical studies examining children exposed to DTG in utero in Botswana.