Award
National Eye Institute 5R01EY010843-32
Regulation of Retinal cGMP-Phosphodiesterases
Recipient
University of Iowa
Award Amount
$347,625.00
Ceiling
$347,625.00
Awarded
December 04, 2025
Identifier
5R01EY010843-32
This NIH grant supports research on the regulation and maturation of retinal cGMP-phosphodiesterases (PDE6), crucial enzymes in vision, aiming to understand their role in retinal diseases and develop new treatments.
Description
The project aims to elucidate the molecular mechanisms underlying the function and regulation of cGMP-phosphodiesterases (PDE6) in rod and cone photoreceptor cells. PDE6 is essential for phototransduction and cell survival. Mutations in PDE6 or its chaperone AIPL1 cause severe retinal diseases such as retinitis pigmentosa, achromatopsia, and Leber congenital amaurosis. The research will focus on the folding and maturation of PDE6, particularly its interaction with the chaperone complex HSP90/AIPL1, to develop new therapeutic strategies.