Award
National Institute of Allergy and Infectious Diseases 7R01AI173077-05
RAG-mediated DNA Damage Responses in Immune Development and Function
Recipient
University of Pittsburgh
Award Amount
$734,616.00
Ceiling
$734,616.00
Awarded
July 16, 2026
Identifier
7R01AI173077-05
This NIH-funded project led by Jeffrey J Bednarski at the University of Pittsburgh studies DNA damage responses in developing B cells to promote normal development and prevent leukemia, focusing on RAG-specific mechanisms and tumor suppressor pathways.
Description
The project involves elucidating mechanisms of DNA damage responses in B cells, focusing on RAG DSBs and their role in preventing leukemogenesis. It aims to identify new approaches for engineering cellular responses to DNA injury and reveal new therapeutic opportunities for B cell leukemia.